For instance, micro organism can cooperate with one another to metabolize complex host molecules, such as glycoproteins, that might be recalcitrant to the action of single species . As proven in Figure 1 bacterial cells are in a position to talk with each other in biofilm communities by way of small diffusible molecules (yellow-colored molecule) . In order to manage, coordinate, and manage communal actions bacterial cells use density-dependent signaling molecules as a “language”. Therefore, micro organism in dental plaque talk with one another by way of quite a lot of chemical signaling molecules . To sum up, bacterial inter-communication is a primary course of supporting colonization and biofilm formation on the dental enamel .